The Queen & Crescent Route was a marketing name used by several associated railroads in the late nineteenth and early twentieth centuries. The name referred to its two primary endpoints: Cincinnati, known as the Queen City of the West, and New Orleans, the Crescent City.
The northern and longest leg of the route was over the Cincinnati, New Orleans & Texas Pacific Railway, running from Cincinnati to Chattanooga. The middle section, the Alabama Great Southern Railroad, linked Chattanooga and Meridian, MS. The southern section from Meridian to New Orleans was by way of the New Orleans & Northeastern Railroad.
A secondary route from Meridian to Shreveport involved two other railroads: The Alabama &Vicksburg Railway and the Vicksburg, Shreveport, & Pacific Railway.
Use of the name began in 1883 and continued well after Southern Railway replaced the earlier companies in 1894.